| Date | Away | Home | |
| Round 1 | 7/04/2018 | Rokewood | Smythesdale |
| Round 2 | 14/04/2018 | Skipton | Smythesdale |
| Round 3 | 21/04/2018 | Smythesdale | Creswick |
| Round 4 | 28/04/2018 | Carngham Linton | Smythesdale |
| Round 5 | 5/05/2018 | Smythesdale | Clunes |
| Round 6 | 12/05/2018 | Springbank | Smythesdale |
| 19/05/2018 | BYE | BYE | |
| Round 7 | 26/05/2018 | Learmonth | Smythesdale |
| Round 8 | 2/06/2018 | Smythesdale | Newlyn |
| 9/06/2018 | BYE | BYE | |
| Round 9 | 16/06/2018 | Daylesford | Smythesdale |
| Round 10 | 23/06/2018 | Smythesdale | Bungaree |
| Round 11 | 30/06/2018 | Gordon | Smythesdale |
| Round 12 | 7/07/2018 | Smythesdale | Buninyong |
| Round 13 | 14/07/2018 | Ballan | Smythesdale |
| Round 14 | 21/07/2018 | Smythesdale | Dunnstown |
| Round 15 | 28/07/2018 | Beaufort | Smythesdale |
| Round 16 | 4/08/2018 | Smythesdale | Hepburn |
| Round 17 | 11/08/2018 | Waubra | Smythesdale |